- Giorno vs Bruno Bucciarati
- Giorno & Koichi vs Black Sabbath
- Giorno, Abbacchio, & Fugo vs Illuso
- Giorno vs Baby Face
- Giorno & Mista vs Ghiaccio
- Giorno & Narancia vs Squalo & Tiziano
- Giorno, Bucciarati, & Trish vs Notorious B.I.G.
- Giorno & Mista vs Cioccolata
- Giorno & Bucciarati vs Secco
- Giorno, Bucciarati, & Polnareff vs Silver Chariot Requiem vs Diavolo
- Giorno, Mista, Trish, Bucciarati, & Polnareff vs Diavolo
Giorno appears as a both support and help Koma-character, and is also the only representative character from Part 5 to appear in the game.
His supports use Gold Experience (2-Koma) or Gold Experience Requiem (3-Koma) to attack with his "MUDAMUDAMUDA!!!" and his help Koma boosts the special attack gauge recovery when blocking or attacking with a support character.
He's one of the 3 characters who serves as an ally boost to DIO (along with Jonathan and Taizou from Taizou Mote King manga series).
Giorno makes his playable debut with the rest of Bucciarati's Gang is one of the main playable characters in the game, being voiced by Romi Park.
He can use his Stand, Gold Experience, to create life and use it to his favor. In an example of the use of his Stand, he can create roots to capture the enemy and give himself a chance to attack. Gold Experience can also create trees to inflict considerable damage, and transform one of Giorno's brooches into a frog, that deflects enemy damage back at them, or a ladybug which follows the enemy (A useless ability added in for comical effect and loyalty to the manga). Giorno's main Stand attack is his "MUDAMUDAMUDA!!!" series of punches (which can be charged to extend the punches' duration).
In all chapter where Giorno is playable (and all the missions in Another Story) aside from the final chapter, he has Gold Experience; In the final battle, he has Gold Experience Requiem. G.E.Requiem possesses most of Golden Experience's attacks, but instead of using its ability to create life, G.E.Requiem will shoot scorpions from its finger not unlike firing bullets as a longed ranged attack. G.E.R can also counter Diavolo's King Crimson's ability: When Diavolo erases time and GER's ability is activated Giorno will stay slowed in the erased time, while G.E.R can freely move and attack Diavolo.
Giorno appears as one of the playable characters in the game. He is voiced by Daisuke Namikawa this time around, with his previous seiyuu, Romi Park, instead voicing Koichi Hirose. He was confirmed for the game alongside Mista, Polnareff and Kakyoin.
Along with Enrico Pucci, Kosaku-Kira, Johnny Joestar, Hol Horse, and Koichi Hirose, Giorno is a character who can utilize more than one Stand during a match as part of his moveset. As one of the mass majority of playable characters in the game with the "Stand" Style, Giorno can turn Gold Experience on/off, changing movesets, as well as having access to the Stand Rush ability returning from the Capcom game, being able to attack in conjunction with his Stand.
- Throw - I must beat them!: Gold Experience uppercuts the opponent, kicks their leg, and beats them.
While Gold Experience is off:
- MUDADA!: Giorno summons Gold Experience to kick the opponent's feet in a low attack, tripping them.
- Now, it lives.: Giorno brings one of his ladybug brooches to life. The resulting animal is dependent on the attack button inputted.
- Light - A flying fish that leaps forward momentarily. (Comboable through Puttsun Cancel)
- Medium - A snake that crawls on the ground and chases the opponent. The opponent is knocked down if they touch it. This version is a low attack that cannot be blocked if the opponent is not crouching. (Comboable)
- Heavy - A piranha that leaps upward. The opponent is stunned and left vulnerable if they touch it. This moves doubles as an anti-air. (Comboable)
- Life, spring forth!: Giorno instantly grows a tree under his feet. This skill can assist in evasion or setting up air attacks.
- This is our true path!: This move can only be used in mid-air. Gold Experience is summoned and sent down to rapidly kick the opponent. This move can be used instantly following "Life, spring forth!".
- It's useless: A counter. Giorno turns one of the ladybug brooches on his chest into a frog. Any attack by the opponent that is not a Throw/HHA/GHA will cause them to be sent into the stage wall, and the ability's damage is proportional to that of the opponent's own attack.
- Now this is a part of me!: Expending half a bar of the HHG, Giorno uses his life-giving ability to heal himself using one of his ladybug brooches. While the health regained is substantial, this ability takes time to perform, and can be interrupted. After it is performed, Giorno must not take any damage for a set period of time in order for the health to successfully recover.
While Gold Experience is on:
- This doesn't feel good...: This ability can only be used when the opponent is down. Gold Experience stomps on them.
- MUDA MUDA MUDA MUDA!: Gold Experience rapidly punches as Giorno walks forward. The opponent is knocked off their feet on the final hit. This ability can initiate Rush Mode. A Stand Rush skill that Giorno can disconnect from to attack the opponent while it is executing. (Comboable through Puttsun Cancel)
- WRYYYYYYYYYY!: Giorno leaps into the air as Gold Experience punches upward. This move acts as an anti-air and has a follow-up.
- MUDAAAAA!: Gold Experience delivers a powerful hook to send the opponent into the ground.
- A path opens on dark plains: A counterattack can only be used once Giorno is hit by any non-Throw/HHA/GHA, or any attack that does not down or send him flying upon the first hit. Gold Experience retaliates by rapidly kicking the opponent away and onto the ground. During this move, Giorno is invulnerable and cannot be hit, even by HHA and GHA. However, the activation costs two stocks of the Heart Heat Gauge to use, and Giorno will suffer a extra small amount of damage, half of which is healable. This move also cannot be Puttsun Cancelled.
Giorno's HHA, "Savor the taste of pain!", is a slow-motion punch to the face from Gold Experience that sends the opponent flying across the stage and leaving them unable to act for a moment afterward on landing (taken from his first encounter with Bucciarati). The HHA will have a different effect depending on the character (such as Gold Experience jabbing its thumb in Jonathan's eye like Dio has, or punching DIO in the upper head like Star Platinum has).
Giorno's GHA, "Your 'end' has no ending!", has him take the Arrow and stab Gold Experience with it in order to evolve it into Gold Experience Requiem, requiring roughly 3 seconds of an animation to play uninterrupted. However, Requiem Mode only lasts until the Heart Heat Gauge empties; GER will revert back to Gold Experience once it runs out. During this mode, Giorno's moveset changes completely, and he cannot turn GER off. Giorno's singular normal attacks do considerable amounts more damage and Puttsun Cancels now spend a fifth of a bar of the Heart Heat Gauge instead of the usual whole stock.
- Beyond the arrow's power: Replacing the normal forward and backward dash, Giorno and Gold Experience Requiem momentarily fly through the air, covering much more ground, potentially passing over the opponent, and evading many attacks. Giorno can perform an air attack during flight.
- Can you escape destruction?: GER fires a scorpion at incredible speed from the tip of its finger. This move is unblockable, and if the opponent is hit, they will be stunned and left vulnerable. (Comboable)
- YOU WILL NEVER REACH TRUTH!: GER unleashes its ability to return any action to zero. In a radius around Giorno, a sphere of black and grey energy will appear and expand. This move is unblockable. If the opponent is caught, they will immediately flinch and be left wide open to attack. This ability can be activated even if Giorno is being attacked. It is also capable of nullifying all projectiles, even those unleashed in HHA and GHA. Using this move expends a fifth of a bar of the HHG. (Comboable)
- MUDA MUDA MUDA MUDA!: GER rapidly punches as Giorno walks forward for 2 to 4 seconds, depending on whether or not the attack button was rapidly pressed. This move has a follow-up if fully completed. (Comboable through Puttsun Cancel)
- MUDAAA!: GER finishes with a singular powerful strike that sends the opponent flying far.
Naturally, Diavolo's "Erasing Time" skill is automatically nullified in Requiem Mode; The ability will initiate as the confirming sound plays, but the time erasure does not actually take effect. If Requiem Mode is active while Enrico Pucci is in "Made in Heaven Mode", the slowdown effect on Giorno will be nullified due to GER's powers, making him one of the only two characters who can truly counter Made in Heaven's effects, the other being "Kosaku Kawajiri's" Bites the Dust.
Alongside the rest of the playable members of Bucciarati's Gang (sans Narancia) and Ermes Costello, Giorno is one of the only characters who activate Resolve Mode instead of the normal Rumble Mode when low on health. In this state, attacks that do not result in hard knockdowns or blow-backs no longer phase the character. Resolve Mode is also activated as a passive effect during Requiem Mode, regardless of health level.
Besides the entire cast from Part 5, Giorno possesses special dialogue before a fight with DIO or Koichi. When fighting Koichi, Koichi will demand his suitcase and passport back (recreating their encounters during early Part 5). While fighting DIO, Giorno admits that DIO was the person he wanted to meet most, and DIO does not recognize him. If Giorno wins, he will say that he will use the power he inherited from him for his own dreams. If DIO wins, he will admit to liking Giorno.
Giorno and Gold Experience also appear on the cover for the Italian version of the game. Since Giorno is never shown in any other outfit, all of his alternate costumes are based on pattern alterations to his outfit shown only in chapter/volume covers or other special pieces of artwork, such as the one based on his Volume 59 appearance and another one based on his Volume 63 appearance.
His solo DHA, WRYYYYYYYYYYY!, has Gold Experience pummeling the opponent at an upward angle over an extended period while the camera shifts perspective multiple times, ending with a downward swinging punch that launches them into the ground (referencing his iconic 7-page long beating of Cioccolata).
With Mista: Mista unloads an entire clip at the opponent, each bullet getting redirected by Sex Pistols multiple times to hit them at different angles. Giorno subsequently appears from behind and jumps high into the air until he is directly above the opponent, proceeding to stomp down on them several times with Gold Experience, the final kick hitting with the impact to launch him off and create a shockwave.
With Bucciarati: The two inform the opponent of their resolve in unison before Gold Experience and Sticky Fingers pummel their target followed by a joint uppercut that sends them high into the air.
With DIO: Gold Experience and The World pummel their target with steadily increasing power, yelling out their shared Stand Cry in unison before they deliver a powerful strike that sends the opponent reeling.
He is paired with Mista in the Eyes of Heaven Tournament, defeating Rohan Kishibe and Polnareff in the first round, and "Kosaku Kawajiri" and Weather Report in the second. In the semifinals, they are defeated by Bucciarati and Trish in the first round.
- His hairstyle is associated with chocolate cornets. The notation "@@@" refers to Giorno's unique hairstyle and is often used by Japanese fans to refer to him.
- Giorno takes after his father's "MudaMudaMuda..." battle cry, only shouting the last "Muda" as a finishing blow. He also lets out a "WRYYYYYY!" during his climactic pummeling of Cioccolata.
- The volume release of Giorno's beatdown on Cioccolata includes two extra pages drawn by Araki. This double page spread was not present in the Weekly Shōnen Jump version. According to JOJO A-GO!GO!, this was the first time in shōnen manga history that a "seven page beatdown" was featured.
- In Araki's top Ten Favorite Characters in 2000, Giorno ranked 5th, Araki's second favorite JoJo and third favorite Part 5 character; Mista ranked 7th, Diavolo at 4th, & Bucciarati in 3rd place.