Manic Depression is a cadaveric looking humanoid creature less than 1 meter tall. Its arms and chest are partially wrapped in bandages. With the exception of its swollen stomach and large skull-like head, the rest of the body is fairly lanky and skeletal.
It can produce thorns from its body and has an umbilical cord-like protrusion coming from its stomach.
Neurochemical Manipulation: Manic Depression is able to increase the biological functions of organisms by piercing them with its thorns. This technique can be used to increase the heart rate (causing it to explode), force irregular stomach digestion, or increase one's physical attributes for a couple of minutes, after which the body breaks down.
It also has the power to convert salt into a powerful opiate, allowing it to be injected for a drug-like effect. The drawback is that the drug formed from the salt only exists for a total of two weeks before reverting back into salt.
- Massimo's stand appears to have abilities opposite of his brother, Tonio's. While Pearl Jam focuses on targeting diseases and issues within the body and heals them, Manic Depression's main purpose is to directly affect neurochemical processes and health with uncertain and negative results.