A Hundred Against Two (100対2のかけひき Hyaku Tai Ni no Kakehiki?) is the twenty-first episode of the JoJo's Bizarre Adventure anime. It is also the twelfth episode of Battle Tendency. It covers Chapter 94 to Chapter 97 of the manga.
Whilst following Wamuu's trail of blood, JoJo and Lisa Lisa encounter another vampire named Wired Beck, but Lisa Lisa manages to defeat him easily. As they press on, JoJo states he will not take the antidote he received until he has beaten Wamuu as a promise to Caesar. They soon arrive before Wamuu, where Kars is also waiting for them, along with a hundred vampire minions. Lisa Lisa manages to hold off their attack with a bluff saying that if both she and JoJo are killed, a time bomb will destroy the stone. Thus, she proposes that JoJo fights against Wamuu whilst she fights against Kars with the stone on the line. Wamuu and Kars arrange a place for the battle at midnight, keeping Lisa Lisa as insurance to make sure JoJo brings the stone. Whilst retrieving the stone, JoJo finds a picture of Erina from fifty years ago, becoming curious as to why Lisa Lisa would have it. Upon meeting at the arena, Lisa Lisa reveals that she was the baby that Erina rescued from the ship that fateful day, further explaining how she was raised by Straizo, who was the one who taught her about the Ripple and gave her the stone. As JoJo and Wamuu's battle is revealed to be a chariot race using vampire horses, JoJo puts on Caesar's bandana and prepares to battle.
- In the manga, Wired Beck uses his ability to grow many spikes all over his body. In the anime, there are much less spikes created than in the manga.
- There is a scene after Kars and Wamuu leave the room, where Joseph forces one of the vampires to bite his own tongue. This was not present in the anime.
- In the manga, Wamuu dresses into his traditional outfit just after stopping the vampire horses. In the anime, he is already seen wearing it upon Joseph's arrival.
- In the manga, after Wamuu chooses the area for their duel and Joseph protests that they're not favorable, a vampire from the ceiling insults Joseph, making Joseph want him to come down. This short scene is cut from the anime.
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